CBD drug interactions
CBD can interfere with the breakdown of certain prescription medicines; this is due to the way in which CBD is metabolised. CBD is metabolised by the cytochrome P450 enzymes, principally CYP3A4 and CYP2D6, and therefore may interact with other prescription medicines that interact with these liver enzymes.
The majority of studies that has been assessed for drug interactions used anti-epileptic drugs, for example CBD was administered at 5mg/kg/day and increased every two weeks up to a maximum dose of 50mg/kg/day with the co-administration of common anti-epileptic drugs such as topiramate, rufinamide and N-desmethylclobazam, decreases in Clobazam serums levels as CBD doses increasedi. While CBD is reported to have minimum adverse events, the potential for drug-drug interaction should be considered based on the patient medication history.
i Russo, E.B., 2019. The case for the entourage effect and conventional breeding of clinical cannabis: no “strain,” no gain. Frontiers in plant science, 9, p.1969.
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