The variance in CBD strengths are the distinguishing factor between the different therapeutic indications.

CBD produces a biphasic response with different doses of CBDⁱ. Dosing is closely related to weight and is reported mg/kg/day. Using the global average body mass of 62 kg (adult) the same conversion rate is used to convert mg/day. For example, 1mg/kg/day is equivalent to 62mg/ day for an average adult. Various scientific literature shows therapeutic CBD doses ranging from 1mg/kg/day to 50/mg/kg dayⁱⁱ. A summary of therapeutic benefits linked to defined CBD doses are presented in Table 1.

 

Table 1. Various therapeutic benefits published in scientific journals using CBD

Therapeutic benefits using CBD	Reported dose*	Scientific paper
Anxiety	1mg/kg/day or less Daily dose of 25mg-75mg	Shannon et al., 2016, Shannon et al., 2019
Cardiovascular diseases	5 mg/kg ip	Durst et al., 2007, Booz 2011
Depression	15, 30 and 45 mg/kg	Shoval et al., 2016
Epilepsy	10mg/kg/day up to 50mg/kg/day	Millar et al., 2019
Hypoxia ischemia injury	1 mg/kg CBD	Pazos et al., 2012
Inflammatory bowel and Chron’s diseases	10 mg/kg	De Flilippis et al., 2011
Insomnia	Daily dose of 25mg-75mg	Shannon et al., 2016, Shannon et al., 2019
Pain	0.4mg/kg/day up to 22.5mg/day	Notcutt et al., 2004
Parkinson’s disease	1.25mg/kg/day to 7mg/kg/day	Khoury et al., 2016
Rheumatoid arthritis	25 mg/kg/day	Malfait et al., 2000
Schizophrenia	1000mg Daily dose	McGuire et al., 2017

*Doses may range from other scientific journals available in the public domain.

i Naftali, T., Mechulam, R., Marii, A., Gabay, G., Stein, A., Bronshtain, M., Laish, I., Benjaminov, F. and Konikoff, F.M., 2017. Low-dose cannabidiol is safe but not effective in the treatment for Crohn’s disease, a randomized controlled trial. Digestive diseases and sciences, 62(6), pp.1615-1620.

ii Millar, S.A., Stone, N.L., Bellman, Z.D., Yates, A.S., England, T.J. and O'Sullivan, S.E., 2019. A systematic review of cannabidiol dosing in clinical populations. British journal of clinical pharmacology, 85(9), pp.1888-1900.