
Scientific studies published using various CBD strengths
The variance in CBD strengths are the distinguishing factor between the different therapeutic indications.
CBD produces a biphasic response with different doses of CBDi. Dosing is closely related to weight and is reported mg/kg/day. Using the global average body mass of 62 kg (adult) the same conversion rate is used to convert mg/day. For example, 1mg/kg/day is equivalent to 62mg/ day for an average adult. Various scientific literature shows therapeutic CBD doses ranging from 1mg/kg/day to 50/mg/kg dayii. A summary of therapeutic benefits linked to defined CBD doses are presented in Table 1.
Table 1. Various therapeutic benefits published in scientific journals using CBD
Therapeutic benefits using CBD |
Reported dose* |
Scientific paper |
Anxiety |
1mg/kg/day or less Daily dose of 25mg-75mg |
Shannon et al., 2016, Shannon et al., 2019 |
Cardiovascular diseases |
5 mg/kg ip |
Durst et al., 2007, Booz 2011 |
Depression |
15, 30 and 45 mg/kg |
Shoval et al., 2016 |
Epilepsy |
10mg/kg/day up to 50mg/kg/day |
Millar et al., 2019 |
Hypoxia ischemia injury |
1 mg/kg CBD |
Pazos et al., 2012 |
Inflammatory bowel and Chron’s diseases |
10 mg/kg |
De Flilippis et al., 2011 |
Insomnia |
Daily dose of 25mg-75mg |
Shannon et al., 2016, Shannon et al., 2019 |
Pain |
0.4mg/kg/day up to 22.5mg/day |
Notcutt et al., 2004 |
Parkinson’s disease |
1.25mg/kg/day to 7mg/kg/day |
Khoury et al., 2016 |
Rheumatoid arthritis |
25 mg/kg/day |
Malfait et al., 2000 |
Schizophrenia |
1000mg Daily dose |
McGuire et al., 2017 |
*Doses may range from other scientific journals available in the public domain.
i Naftali, T., Mechulam, R., Marii, A., Gabay, G., Stein, A., Bronshtain, M., Laish, I., Benjaminov, F. and Konikoff, F.M., 2017. Low-dose cannabidiol is safe but not effective in the treatment for Crohn’s disease, a randomized controlled trial. Digestive diseases and sciences, 62(6), pp.1615-1620.
ii Millar, S.A., Stone, N.L., Bellman, Z.D., Yates, A.S., England, T.J. and O'Sullivan, S.E., 2019. A systematic review of cannabidiol dosing in clinical populations. British journal of clinical pharmacology, 85(9), pp.1888-1900.
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