Scientific studies published using various CBD strengths

Scientific studies published using various CBD strengths

 

The variance in CBD strengths are the distinguishing factor between the different therapeutic indications.

CBD produces a biphasic response with different doses of CBDi. Dosing is closely related to weight and is reported mg/kg/day. Using the global average body mass of 62 kg (adult) the same conversion rate is used to convert mg/day. For example, 1mg/kg/day is equivalent to 62mg/ day for an average adult. Various scientific literature shows therapeutic CBD doses ranging from 1mg/kg/day to 50/mg/kg dayii. A summary of therapeutic benefits linked to defined CBD doses are presented in Table 1.

 

Table 1. Various therapeutic benefits published in scientific journals using CBD

Therapeutic benefits using CBD

Reported dose*

Scientific paper

Anxiety

1mg/kg/day or less

Daily dose of 25mg-75mg

Shannon et al., 2016, Shannon et al., 2019

Cardiovascular diseases

5 mg/kg ip

Durst et al., 2007, Booz 2011

Depression

15, 30 and 45 mg/kg

Shoval et al., 2016

Epilepsy

10mg/kg/day up to 50mg/kg/day

Millar et al., 2019

Hypoxia ischemia injury

1 mg/kg CBD

Pazos et al., 2012

Inflammatory bowel and Chron’s diseases

10 mg/kg

De Flilippis et al., 2011

Insomnia

Daily dose of 25mg-75mg

Shannon et al., 2016, Shannon et al., 2019

Pain

0.4mg/kg/day up to 22.5mg/day

Notcutt et al., 2004

Parkinson’s disease

1.25mg/kg/day to 7mg/kg/day

Khoury et al., 2016

Rheumatoid arthritis

 25 mg/kg/day

Malfait et al., 2000

Schizophrenia

1000mg Daily dose

McGuire et al., 2017

*Doses may range from other scientific journals available in the public domain.

i Naftali, T., Mechulam, R., Marii, A., Gabay, G., Stein, A., Bronshtain, M., Laish, I., Benjaminov, F. and Konikoff, F.M., 2017. Low-dose cannabidiol is safe but not effective in the treatment for Crohn’s disease, a randomized controlled trial. Digestive diseases and sciences, 62(6), pp.1615-1620.

ii Millar, S.A., Stone, N.L., Bellman, Z.D., Yates, A.S., England, T.J. and O'Sullivan, S.E., 2019. A systematic review of cannabidiol dosing in clinical populations. British journal of clinical pharmacology85(9), pp.1888-1900.

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