CBD and anti-inflammatory properties
CBD is known to have anti-inflammatory properties, in the case of an inflammatory response where a “cytokine storm” occurs, CBD may be beneficial in dampening down the effects of an influx of cytokines. Cytokines are involved in the immune response however the release of a large amount can be harmful.
Therefore it is not surprising there is emerging evidence that CBD has a potential therapeutic role in COVID-19. In the first stage of the disease (SARS-CoV-2) treatment strategies look at measures to reduce the virus load and boost the immune system are imperative to reduce the impact of the virus. However various studies have shown treatment that dampen down the immune system may have increased risk of complication such treatment includes nonsteroidal anti-inflammatory (NSAID). However, it is evident at some point during the progression and exacerbation of the disease immunosuppression can save lives. Many drugs are known to interfere with steps of this inflammatory chain reaction such as corticosteroids, cyclosporine, IL-6 inhibitors or Janus-kinase inhibitors (JAK-inhibitors), each having its own mechanism and its own benefits and adverse events. Researchers are now looking at the effects that CBD can have in normalising the physiologic redox balance. CBD has various mechanisms in which homeostasis is achieved as a potent is a potent immunomodulator. CBD also has strong antioxidant effects; reports suggest that CBD exceeds vitamin E and C in capturing free radicals this can prove to be highly effective in a virus infected celli. In addition, SARS-CoV-2 enters the human host through angiotensin-converting enzyme II (ACE2), this enzyme is expressed in lung tissue, as well as oral and nasal mucosa, kidney, testes, and the gastrointestinal tract. CBD is known to downregulate the ACE2 thereby potentially halting the spread of SARS-CoV-2ii.There are various scientific institutions assessing CBD potential role in the treatment of SARS-CoV-2.
i Gerhard Nahler, Eberhard Pirich, Trevor M Jones (2020) COVID-19 Related Lung Inflammation and Oxidative Stress – a Role for Cannabidiol ?. J Pharmacol Pharm Res Volume 3(1): 1-4.
ii Wang, B.; Kovalchuk, A.; Li, D.; Ilnytskyy, Y.; Kovalchuk, I.; Kovalchuk, O. In Search of Preventative Strategies: Novel Anti-Inflammatory High-CBD Cannabis Sativa Extracts Modulate ACE2 Expression in COVID-19 Gateway Tissues. Preprints 2020, 2020040315 (doi: 10.20944/preprints202004.0315.v1).
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